Chemical name: Phosphoramidothioic acid, O,S-dimethyl ester

Final regulatory action has been taken for the category: Pesticide

Final regulatory action: The chemical is Severely Restricted

Use or uses prohibited by the final regulatory action:

Formulations containing until 600 g/L active ingredients.

Pesticide use or uses that remain allowed:

Formulations containing until 600 g/L active ingredients.

The final regulatory action was based on a risk or hazard evaluation: Yes

Summary of the final regulatory action:

Law No. 7.802 of 11 July 1989 and Decree No. 4.074 of 4 January 2002 - Pesticides and its compounds need to be registered by the Federal Authority prior to produce, export, import, trade or use.

The reasons for the final regulatory action were relevant to: Human health and environment

Summary of known hazards and risks to human health:

Methamidophos is a highly active, systemic, residual organophosphate insecticide/acaricide/avicide with contact and stomach action. Its mode of action in insects and mammals is by decreasing the activity of an enzyme important for nervous system function called acetylcholinesterase. This enzyme is essential in the normal transmission of nerve impulses. Methamidophos is a potent acetylcholinesterase inhibitor.

Expected effect of the final regulatory action in relation to human health:

To avoid exposure of the chemical and the associated risks to human health.

Summary of known hazards and risks to the environment:

Generally, methamidophos is not considered phytotoxic if used as directed, but defoliation has occurred when applied as foliar spray to deciduous fruit. It is compatible with many other pesticides, but do not use with alkaline materials. Methamidophos is slightly corrosive to mild steel and copper alloys. This compound is highly toxic to mammals, birds, and bees. Do not graze treated areas, and be sure to wear protective clothing including respirator, chemical goggles, rubber gloves, and impervious protective clothing.

Expected effect of the final regulatory action in relation to the environment:

To avoid exposure of the chemical and the associated risks to environment.

Date of entry into force of the final regulatory action: 04/01/2002