Chemical name: Phosphorothioic acid, O,O-diethyl O-(1-phenyl-1H-1,2,4-triazol-3-yl) ester

Final regulatory action has been taken for the category: Pesticide

Final regulatory action: The chemical is Banned

Use or uses prohibited by the final regulatory action:

All uses and formulations of Triazophos are severely restricted

The final regulatory action was based on a risk or hazard evaluation: Yes

Summary of the final regulatory action:

All products containing Triazophos are restricted because of their high potential of toxicity to human beings and to the environment.

The reasons for the final regulatory action were relevant to: Human health and environment

Summary of known hazards and risks to human health:

Triazophos is highly acutely toxic to human beings and mammals. Oral LD50 is 66 mg/kg in rats (Footprint PPDB, 2014). It is mildly to moderately toxic if absorbed through the skin. The dermal LD50 in rabbits is higher than 2000 mg/kg body weight.

Clinical signs and symptoms recorded after human ingestion of triazophos include runny nose, watery eyes, transpiration, increased salivation, weakness, agitation, sneezing, slime, respiratory problems, dizziness, headaches, nausea, vomiting, diarrhoea, abdominal cramps, pneumonia, productive cough, blurred vision, incontinence, abnormal heart rhythm, convulsions (see annex).

The pilot study on poisoning deriving from agricultural pesticides in Burkina Faso showed that the active matter triazophos is used by producers even though it is no longer registered by the CSP. It was found in the following formulations: CYPERPHOS 186 EC (Cypermethrine+ triazophos) and DELTAPHOS 210 EC (deltamethrine + triazophos). The following table shows the poisoning incidents related to the use of triazophos recorded by producers.

Table I - .Poisoning incidents recorded by producers related to the use of DELTAPHOS

Commercial name DELTAPHOS 210 EC (deltamethrin +triazophos)

Type of pesticide: insecticide

Classified by WHO as: Ib

Registration by CSP: No

Type of incident: skin

Number of cases: 04

Symptoms of poisoning : Itching, burning, fever, abdominal pain, scars, fainting

Inhalation

Number of cases: 08

Symptomes of poisoning: Breathing problems, headache, dizziness, abdominal pains, vomiting

Eyes

Number of cases: 01

Symptomes of poisoning: Eye burns

Ingestion

Number of cases: 01

Symptoms of poisoning: Transpiration, vomiting, diarrhoea

Expected effect of the final regulatory action in relation to human health:

The reduction of risks from the use of triazophos

Summary of known hazards and risks to the environment:

Mammals: the oral acute toxicity is high in rats in which the measured LD50 was 66 mg/kg (Footprint PPDB, 2014).

Wild bird : the oral acute toxicity is high in Colinus virginianus in which LD50 is 8,3 mg/kg) (Footprint PPDB, 2014). 5

Fish: the oral acute toxicity 96 h is high in Oncorhynchus mykiss in which LC50 is 0,038 mg/l (Footprint PPDB, 2014).

Expected effect of the final regulatory action in relation to the environment:

The reduction of risks from the use of Triazophos

Date of entry into force of the final regulatory action: 08/04/2015